David R. Meldrum, MD

Save the dates! July 30-August 1, 2018

In 2016 the University of California Comprehensive Course on IVF ET moved to a a spectacular new venue at the historic Del Coronado Hotel and Resort on the beach on Coronado Island in the vacation wonderland of San Diego, California. Click on the menu to the left ("Coronado Island"). map

More information regarding the 2018 course is available online by visiting:

  https://cme.ucsd.edu/ivf

For further questions, contact:

Bermellyn Imamura, (858)822-4770, email bimamura@ucsd.edu 

2018 Plenary lecture schedule

Coronado aspects not covered

*click (ONCE) to enlarge personal images

Scotland OldmeldrumMost people feel more comfortable with their physicians if they know a lot about them. Certainly you want to know their education and qualifications, but you may also like to know their personal interests, or research, or their most cherished accomplishments during their career. At the very least it gives you something to talk about, particularly if the person is on the quiet side, like yours truly. Above all, don't equate being quiet with lack of interest. One thing you can be sure of is that I will always be thinking of how to provide you with the best chance of success with the least expense (part of my Scottish background) and risk.

Education and training
I'm originally Canadian, brought up in the prairies in Regina, Saskatchewan. I was fortunate to earn a scholarship to do a combined science and medicine course at McGill University, where I received a bachelor of science with great distinction and graduated first in my class for my MD. Incidentally that wasn't something I was really trying to do. I just love the process of learning and I did something quite unusual in never taking any notes. I figured that anything that was really important I would hear at least a half dozen times and if my mind set was learning it instead of writing it down to learn it later, it would be mine. Needless to say my classmates thought I was nuts, but it worked well, and "the proof is in the pudding".

McGillWhen I finished my medical training there was a lot of political unrest in French Canada where McGill is located. I had developed a travel bug by doing externships in Jamaica and Florida, so I set off for an internship in Los Angeles at Harbor-UCLA, which was reputed to be one of the top in the U.S. There I met and married Claudia, who is a native Californian. I had enjoyed doing obstetrics so I then applied to UCLA and completed my OB/GYN residency there in Westwood.

My interest in infertility arose very much out of our difficulty conceiving. When I finished my residency a vacancy on the faculty in infertility opened up and I became the principal person doing infertility surgery at UCLA for the next dozen years. quads strollersClaudia didn't ovulate with clomid and fertility specialists were just beginning to use gonadotropins. However, we did not have ultrasound or estrogen levels for monitoring. After 5 failed cycles of Pergonal (like menopur today) we took a relaxing 6 months doing research in Madrid and the first cycle on our return resulted in the Meldrum quadruplets (see “quads”)! I've always thought the lack of stress made a difference, but she did also gain a little weight.

I was fortunate to be able to take a fellowship in reproductive endocrinology and infertility while I was a faculty member (I was already doing essentially only infertility clinically and for my research). I then received my subspecialty board accreditation shortly thereafter.

My interest in IVF arose directly out of my involvement in tubal surgery (there had to be a better way than trying to repair badly damaged fallopian tubes), but it was also spurred by a patient whose ovaries had failed to develop. I remember that we had to remove her ovaries because of their risk for tumors. It was a couple of years before the first IVF success in 1978 in Great Britain (Louise Brown) but I was aware of the work being done. grand roundsI did not remove my patient's uterus and recall being roundly criticized by my fellow faculty members when we presented the case at grand rounds. When I told them that some day she would have children from donated eggs they looked at me like I was from another planet. She subsequently had two successful pregnancies and I saw her for many years for hormone replacement.

Research interests

Salk InstituteAlthough my initial research interest while on full time faculty at UCLA was related mainly to menopause, I was intrigued by a new class of drugs called GnRH agonists. Together with the Salk Institute (above) I was first to publish the use of an agonist in women with endometriosis. That work of course developed into the use of Lupron as a new treatment for endometriosis, but it also led to my interest in using GnRH agonists as adjuncts for ovulation induction. I was subsequently one of the first to investigate the use of Lupron for IVF and was the first to suggest its routine use (the benefits for synchronized growth of the follicles and for preventing ovulation before the eggs could be retrieved were very large). Even so, it took a few years until virtually all IVF programs were using an agonist initially for all patients. Throughout my career I have maintained ovulation induction as one of my main research interests (see publications).

More recently I have developed an interest in the effects of lifestyle and nutrition on IVF results, which is becoming an area of major interest (see "Lifestyle and fertility" and www.lifechoicesandfertility.com). Studies have also shown that sexual dysfunction is common in infertility patients, and I have recently published on erectile function and its relationship to vascular health in general.Survival of the Firmest Together with Lou Ignarro, PhD, who is a UCLA researcher who shared the 1998 Nobel Prize for discovering the role of nitric oxide in erectile and vascular health, and researchers in Naples, Italy who have also done excellent work in this area, I have published 4 major reviews on this topic. Infertile couples experiencing sexual dysfunction will find our web site, www.erectile-function.com , very helpful in restoring or maintaining a satisfying sexual relationship. Its home page has links directly to those reviews, which any sexually active male will find very helpful in addition to all of the information on the site and in our book "Survival of the Firmest".

Accomplishments
I have always enjoyed the development of knowledge, which of course stems from individual, well-designed studies. Fertility and SterilityI've served as an ad-hoc reviewer for several journals and I have been an editorial board member for Fertility and Sterility for approximately 20 years. I am presently an editorial editor, which allows me to be involved in writing and editing review articles. Most people don't realize how important review articles are. There is always a long delay between publication of definitive research and when new treatments are widely adopted in practice. For example, at the Mayo Clinic a study was done showing that a short course of antibiotics was equally effective for bladder infections compared with 10 days of treatment, but it took about 10 years until they uniformly applied their own research in care of their patients. That finally resulted from review articles that gave practitioners "permission" to change their care. Another example in our field is the use of growth hormone for poor responders. The research is quite definitive and the benefit appears to be large, yet only a minority of IVF practitioners use it. It is hoped that articles such as one I did with colleagues around the world discussing "orphan adjuncts" and a review article which I co-authored with colleagues in Europe on the value of growth hormone supplements in ART will encourage others to adopt this highly effective treatment.

SARTI was fortunate to serve as the first commissioner for reproductive lab accreditation, which is now a highly effective program helping to standardize IVF lab quality across the U.S. I also have served as president of the Society for Assisted Reproductive Technology and the Pacific Coast Reproductive Society.

I continue to enjoy teaching in spite of leaving the full-time UCLA faculty many years ago. At present I am a Clinical Professor at UCLA and UCSD. At UCSD I attend a monthly journal club where I contribute to analysis of new research together with UCSD faculty and fellows and RPMG physicians from our facility in La Jolla.

Santa Barbara ConferencePerhaps the professional accomplishment I am most proud of is my 28 years organizing and directing the UCLA comprehensive postgraduate course on IVF, which has taken place each July in Santa Barbara. It is widely recognized as the top postgraduate course in IVF, and because it is so well attended, I have been able to invite a large number of highly respected speakers from around the world. I remember several years ago it was even attended by people who had originally been involved in my training in Australia before setting up the UCLA IVF program (see "Australia to UCLA").

China dinnerI would also have to list being involved in achieving the first IVF success in China, following an extended visit by a team in Beijing while I was at UCLA (see "China").

One of my proudest accomplishments is the people I have trained. At the top of that list are Dr. Gabe Garzo, who runs our La Jolla facility, and Dr. William Schoolcraft, who runs the Colorado Center for Reproductive Medicine. Those two programs have some of the best results in the nation. I could list numerous others, but Gabe and Bill have become truly stellar IVF clinicians and Bill has published numerous excellent IVF papers. Bill now co-directs the UCLA Santa Barbara meeting with me.

quads, waterfall

Of course like any father my greatest accomplishment has been to raise our four kids, who are each successful in their chosen fields and who all have big hearts. My passion for flying (see "Angel Flight") allows us to see Erik in northern California and we enjoy getting together each year for their birthday (now also with 3 grand kids and 2 grand dogs)!

grand kids

grand dog

Appointments:

I am no longer seeing patients, but I continue to be the scientific director of Reproductive Partners Medical Group in La Jolla, where we have made it a prority to transfer a single high quality embryo in as many of our patients as possible, to avoid the very significant complications of multiple pregnancy for both mother and her newborn. We currently have one of the highest implantation rates in the nation. To learn more or to see one of our physicians, go to our website.