David R. Meldrum, MD

Coronado 2018 lecture schedule

COURSE CHAIR

Jeffrey Chang, MD
Professor, Department of Reproductive Medicine
UC San Diego School of medicine

COURSE DIRECTOR

David R. Meldrum, MD

Scientific Director, Reproductive Partners San Diego, La Jolla, California; Clinical Professor, Department of Reproductive Medicine, Division of Reproductive Endocrinology and Infertility, UC San Diego, and David Geffen School of Medicine at UCLA

COURSE CO-DIRECTOR

William B. Schoolcraft, MD

Medical Director, Colorado Center for Reproductive Medicine, Lone Tree, Colorado,

Scientific Co-director, Reproductive Partners San Diego, La Jolla, California

Professor, Division of Reproductive Endocrinology and Infertility, Department of Reproductive Medicine, University of California at San Diego

GUEST FACULTY

Diana Alecsandru, MD, PhD

Department of Immunology and Department of Reproductive Endocrinology and Infertility, Instituto Valenciano de Infertilidad (IVI), Madrid, Spain

Robert Casper, MD

Professor, Division of Reproductive Sciences, University of Toronto; Camille Dan Family Research Chair in Translational Cell Biology and Senior Scientist, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada

Dominique de Ziegler, MD

Professor of Gynecology, University Consultant University of Paris Ouest - Hospital Foch

Antoni J. Duleba, MD

Professor and Chief, Division of Reproductive Endocrinology and Infertility, Department of Reproductive Medicine, University of California at San Diego

Daniel A. Dumesic, MD

Division Chief, Reproductive Endocrinology and Infertility, Professor, Department of Obstetrics and Gynecology, David Geffen School of Medicine, Los Angeles, California

Joseph C. Gambone, DO, MPH

Professor Emeritus of Obstetrics and Gynecology, David Geffen School of Medicine, Los Angeles, California

Gabriel Garzo, MD

Clinical Professor, University of California, San Diego; Medical Director, Reproductive Partners San Diego, La Jolla, California

Mandy Katz-Jaffe, PhD

Scientific and Genetics Director, Colorado Center for Reproductive Medicine, Lone Tree, Colorado, Adjunct Clinical Associate Professor, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Colorado Denver, Clinical Instructor, Division of Reproductive Endocrinology and Infertility, Department of Reproductive Medicine, University of California at San Diego

Stephen A. Krawetz, PhD

Associate Director C.S. Mott Center for Human Growth and Development, Charlotte B. Failing Professor of Fetal Therapy and Diagnosis, Department of Obstetrics and Gynecology, Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI

Shoukhrat Mitalipov, PhD

Director, Oregon Health and Science University Center for Embryonic Cell and Gene Therapy, Portland, Oregon

Kelle H. Moley, MD

Professor and Vice Chair of Obstetrics and Gynecology, Washington
University School of Medicine, St. Louis, MO

Richard J. Paulson, MD

Professor, Obstetrics and Gynecology; Chief, Division of Reproductive Endocrinology and Infertility, University of Southern California School of Medicine

Antonio Pellicer, MD

Professor of Obstetrics and Gynecology, University of Valencia, Spain; Founder, Insituto Valenciano de Infertilidad (IVI), IVI, Rome, Italy

Gianpiero Palermo, MD, PhD

Professor of Reproductive Medicine, Director of Andrology and Assisted Fertilization, Weill Cornell Medicine, Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, New York, NY

Catherine Racowsky, PhD, HCLD

Professor of Obstetrics & Gynecology, Harvard Medical School, Director, IVF Laboratory, Brigham and Women's Hospital, Boston, MA

Denny Sakkas, PhD

Scientific Director, Boston IVF, Waltham, Massachusetts

Peter Schlegel. MD

James J Colt Professor & Chairman of Urology, Professor of Reproductive Medicine, Weill Cornell Medicine, New York, NY

Richard T. Scott, Jr.

MD, HCLD; Professor and Director, Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology and Reproductive Science, Robert Wood Johnson Medical School - UMDNJ; Scientific Director, Reproductive Medicine Associates of New Jersey, Morristown, New Jersey

Jason E. Swain, PhD, HCLD

Corporate Lab Director, CCRM IVF Laboratory Network, Englewood, CO; Adjunct Clinical Associate Professor, Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology and Reproductive Science Rutgers University, Robert Wood Johnson Medical School, Piscataway, NJ; Adjunct Clinical Associate Professor, Department of Obstetrics, Gynecology and Women's Health, University of Minnesota, Minneapolis, MN

Bill Yee, MD

President and Medical Director, Reproductive Partners Medical Group, Westminster, California; Clinical Professor, Department of Obstetrics and Gynecology, University of California, Irvine

PROGRAM

Monday, July 30 Morning

7:00

Continental Breakfast/Exhibits

8:00

Introduction, Jeffrey Chang, MD

8:10

 

Impact of Stress, Counseling, Acupuncture, Smoking, Alcohol, Caffeine, Exercise, Nutrition, sexual function, Supplements - lifestyle factors should be corrected 3-6 months before IVF

David R. Meldrum, MD

8:35

 

 

Simulation strategies for the poor responder

William B. Schoolcraft, MD

Focus Session – Alternatives to Full stimulation and Fresh Transfer

8:55

 

Ovarian stimulation impairs the implantation of slowly developing embryos, which is not apparent on day 3 assessment and is further compromised by increased serum progesterone

Richard T. Scott, Jr., MD

9:15

 

 

Panel--Questions and answers

Drs. Schoolcraft, Scott

Moderator: Dr. Meldrum

9:30

Coffee Break/Exhibits

10:00

 

Natural and modified natural cycles – what is the evidence that gonadotropin stimulation is bad for eggs?

Richard Paulson, MD

10:15

 

With vitrification and deferred transfer, is clomiphene citrate the new “natural” cycle?

Bill Yee, MD

10:30

 

Clomiphene citrate/gonadotropins

Antoni Duleba, MD

10:45

 

 Etiology, Prevention and Treatment of Ovarian Hyperstimulation – agonist trigger with “freeze all” is the best prevention

Antonio Pellicer, MD

11:15

 

Deferred transfer results in increased implantation and reduced perinatal complications.

Antony Duleba, MD

11:40

 

Adjuncts to stimulation - agonists, OC, estrogen, LH, low dose aspirin, growth hormone, testosterone, Letrozole, DHEA, dexamethazone.

David Meldrum, MD

12:10

 

Panel – Q&A - the future of COH

Moderator David Meldrum

12:30

Lunch

Monday, July 30, Afternoon 

1:30

Transvaginal Follicle Aspiration – Making Difficult Retrievals Easier and Minimizing Risks

David R. Meldrum, MD

2:00

Questions and Answers

2:10

Medical and Surgical Treatment of Endometriosis before IVF:  Help or Harm?

Dominique de Ziegler, MD

2:50

Questions and Answers

3:00

Coffee Break/Exhibits

3:30

Fertility preservation for the Woman with Cancer

Irene Su, MD, MSCE

4:00

Questions and Answers

4:10

Impact of Obesity on fertility

Kelle H. Moley, MD

4:30

Uterine defects and implantation

Tuesday, July 31, Morning

7:00 

Continental Breakfast/Exhibits

8:00 

 

Time lapse is helpful for day 3 transfers but may not predict blastocyst normality and competence

Catherine Racowski, PhD

8:20

Questions and Answers

8:30

Factors influencing the choice of cleavage or extended culture

Jason Swaine, PhD

8:50

Questions and Answers

9:00 

Mitochondria are a vital source of energy in cumuli, oocytes, and embryos: the effects of aging

Robert Casper, MD

9:20

Questions and answers

9:30 

Single embryo transfer- the ultimate goal to optimize IVF outcomes

Gabriel Garzo, MD

9:50

Questions and answers

10:00 

Coffee Break/Exhibits

10:30

Genetic evaluation of the Infertile Couple: from Pre-Conception to NIPT

Mandy Katz-Jaffe, PhD

11:00

Questions and Answers

11:10

Maternal immunogenetics influences IVF and oocyte donation live birth rates

Diana Alecsandru, MD, PhD

11:40

Questions and Answers

11:50

 

 

40th anniversary of IVF Keynote lecture

Gene editing of embryos and stem cells as a source of sperm and oocytes - what will the next 40 years bring to ART?

Shoukhrat Mitalipov, PhD

12:25

40th anniversary of IVF presentation honoring Gianpiero Palermo, MD, PhD for reporting the first successful ICSI

12:30 

Lunch

Tuesday, July 31,  Afternoon

1:30 

 

Male evaluation and the role of genetic and DNA fragmentation testing

Peter N. Schlegel, MD

1:50

Questions and Answers

2:00

 

Sperm retrieval – preparation, technique, fresh or frozen, and when should attempting retrieval be deemed futile?

Peter N. Schlegel, MD

2:20

Questions and Answers

2:30 

The role of the sperm in achieving the best embryos in vitro

Denny Sakkas, PhD

2:50

Questions and Answers

3:00 

The difficult ICSI cases- cryptozospermia, immotile sperm, and where ICSI has previously failed

Gianpiero Palermo, MD, PhD

3:20

Questions and answers and 40th Anniversary of IVF Award as the person who reported the first successful ICSI

3:30 

Coffee Break/Exhibits

4:00 

Mosaicism - incidence, causes, implications and potential outcomes with transfer

Mandy Katz-Jaffe, PhD

4:20

Questions and Answers

4:30

 

DEBATE: PGS - INDISPENSABLE OR TOO INACCURATE FOR CLINICAL USE? 

Sampling error is too great to avoid diagnostic errors and discarding embryos capable of normal development

Richard Paulson, MD

4:50

PGS errors are sufficiently infrequent to be insignificant compared to the alternative of multiple failed transfers, unnecessary fetal losses, delayed success and treatment drop-outs

Richard T. Scott, Jr., MD

5:00 

 

Awakening oocytes in women with premature ovarian failure

Antonio Pellicer, MD

5:20

Questions and Answers

5:30

Adjourn

Wednesday, July 1, Morning

7:00  

Continental Breakfast/Exhibits

8:00  

Some adverse outcomes are increased with ART--is prevention possible and what should we be telling our patients?

Joseph C. Gambone, DO, MPH

8:30  

Questions and Answers

8:40  

The endometrium and IVF- morphologic and histopathology changes preventing ongoing pregnancy

Dominique de Ziegler, MD

9:10  

Questions and Answers

9:20  

Transfer technique- the precision of ultrasound-guided transfer is crucial for SET

William Schoolcraft, MD

9:50  

Questions and Answers

10:00 

Coffee Break/Exhibits

10:30

Optimizing hormone replacement and timing for oocyte donation and deferred transfer

Robert Casper, M.D.

10:50:

Questions and answers

11:00

The Barker hypothesis and epigenetics - optimizing the health of our IVF offspring

Daniel A. Dumesic, MD

11:20 

Questions and Answers

11:30

Are immune and thrombophilia tests useful prior to IVF?  When and for whom should these tests be offered?

Diana Alecsandru, MD, PhD

11:50 

Questions and Answers

12:00

 

Panel: Summary and last chance for questions regarding all sessions.

Drs Gambone, de Ziegler, Schoolcraft, Casper, Dumesic, Alecsandru

Moderator: Dr. Meldrum

12:20

 Adjourn

Wednesday, July 1, Afternoon

OPTIONAL MINI-SYMPOSIUM ON THE IVF LABORATORY

Bill Schoolcraft, MD, Director

1:30-2

 Piezo ICSI – a better approach?  (Testunori Mukaida, PhD)

2-2:30

Spindle transfer for mitochondrial replacement therapy – is it safe? (Jacques Cohen, PhD) 

2:30-3

Electronic lab witnessing (Rebecca Holmes PhD, HCLD)

3-3:30

Break

3:30-4

Artificial intelligence and automation in the IVF lab? (Charles Bormann PhD HCLD

4-4

Can the lab really influence aneuploidy?  Please prove it.  Jason Swain, PhD, HCLD)  (con)

4:30-5

Non-invasive assessment of embryo viability-cell free DNA, metabolomics and more (D. Sakkas)

 

Appointments:

I am no longer seeing patients, but I continue to be the scientific director of Reproductive Partners Medical Group in La Jolla, where we have made it a prority to transfer a single high quality embryo in as many of our patients as possible, to avoid the very significant complications of multiple pregnancy for both mother and her newborn. We currently have one of the highest implantation rates in the nation. To learn more or to see one of our physicians, go to our website.